Phases of the Cell Cycle

Phases of Cell Cycle

Human cells in culture provide an example of a normal eukaryotic cell cycle. Every 24 hours or so, these cells divide once. The length of the cell cycle can, however, differ from organism to organism and from cell type to cell type. For instance, yeast may complete the cell cycle in about 90 minutes.

Interphase and M Phase(Mitosis phase) are the two fundamental phases of the cell cycle.

Interphase

A cell spends the majority of its time in what is known as interphase, where it develops, duplicates its chromosomes, and gets ready to divide. The cell then exits interphase, goes through mitosis, and finishes dividing. The phases of interphase are G1 phase (cell growth), S phase (DNA synthesis), and G2 phase (cell growth). The mitotic phase, which consists of mitosis and cytokinesis and produces two daughter cells, begins after interphase. In the cell cycle, the interphase is a protracted resting phase during which , DNA is replicated, RNA is synthesised, and proteins are produced.

The transitional period between mitosis and the start of DNA replication is known as the G1 phase. The cell is metabolically active and continues to develop during the G1 phase but does not duplicate its DNA. The time when DNA synthesis or replication occurs is known as the "S" phase. The amount of DNA in each cell doubles throughout this period. DNA grows from 2C (the initial amount) to 4C (the final amount). However, the number of chromosomes does not grow; if the cell had diploid or 2n chromosomes at G1, the number of chromosomes continues to be 2n even after S phase.In animal cells, the centriole doubles in the cytoplasm and DNA replication starts in the nucleus during the S phase. Proteins are created during the G2 phase as cells continue to expand in preparation for mitosis.Thus interphase is vital in the cell cycle as it permits the cell to grow and develop into a mature cell before it is able to reproduce.

Heart cells are one type of cell that does not appear to divide in adult animals, and many other cells only sporadically divide when it is necessary to replenish cells lost to damage or cell death. These cells leave the G1 phase and enter the quiescent stage (G0), which is an inactive phase of the cell cycle. While still metabolically active, cells in this stage no longer divide unless specifically instructed to do so by the organism. Only the diploid somatic cells in animals undergo mitotic cell division. In contrast, both haploid and diploid cells in the plants can exhibit mitotic divisions.

M Phase

It is the most dramatic phase of the cell cycle and involves a significant reorganisation of almost all cell components. It is also known as equational division since both the parent and progeny cells have the same number of chromosomes. Although mitosis has been conveniently split into four stages of nuclear division, it is crucial to realise that cell division is a progressive process, and extremely obvious distinctions between different stages cannot be made. Two processes make up the M phase: cytokinesis (or cell division), in which a cell's cytoplasm splits in half to create two different daughter cells, and mitosis, in which the cell's chromosomes are divided equally between the two daughter cells.